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KMID : 0380620210530010072
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 1 p.72 ~ p.77
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Evaluation of the effects of Hangover-releasing agent containing freeze-dried mature silkworm larval powder (SMSP) on alcohol metabolism and hangover improvement
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Woo Mi-Seon
Cha Ji-Hyeon
Kim Yong-Hwan
Kang Hee-Taik
Kim Hyeon-Dok
Cho Kyong-Won
Park Sung-Sun
Lee Jong-Hun
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Abstract
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Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.
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KEYWORD
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hangover improvement, silkworm (Bombyx mori) powder, alcohol metabolism, clinical trail research, cross-over model
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